In fourteen scholarly yet delightfully readable essays, Ober solves some ancient mysteries and reveals the secret kinks and passions of famous and obscure historical figures.

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

This book provides a unique, cogent, engaging account of environmental determinism that has long been much needed in the classroom and beyond." -- Andrew Sluyter, Associate Professor, Louisiana State University, USA This book pulls together major critiques of contemporary attempts to explain nature-society relations in an environmentally deterministic way. After defining key terms, it reviews the history of environmental determinism's rise and fall within geography in the early twentieth century. It discusses the key reasons for the doctrine's rejection and presents (...) alternative, non-deterministic frameworks developed within geography for analyzing the roles played by the environment in human affairs. The authors examine the rise in recent decades of neo-deterministic approaches to such issues as the demarcation of regions, the causes of civilizational collapse in prehistory, today's globally uneven patterns of human well-being, and the consequences of human-induced climate change. In each case, the authors draw on the insights and approaches of geography, the academic discipline most conversant with the interactions of society and environment, to challenge the widespread acceptance that such approaches have won. The book will appeal to those working on human-environmental research, international development and global policy initiatives. William B. Meyer is Associate Professor of Geography at Colgate University, USA. He is the author of several previous books, including Human Impact on the Earth, Americans and Their Weather: A History, and The Progressive Environmental Prometheans. His research interests include urban geography, environmental history, and the history of environmental thought. Dylan M.T. Guss works in the technology investment sector. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:MIMESIS AND EMPATHY IN HUMAN BIOLOGY William B. Hurlbut, M.D. Stanford University Thou shalt not avenge, nor bear any grudge against the children of thy people, but thou shalt love thy neighbor as thyself: I am the Lord. (Leviticus. 19:18) The light of the body is the eye: if therefore thine eye be single, thy whole body shall be full of light. But if thine eye be evil, (...) thy whole body shall be full of darkness. If therefore the light that is in thee be darkness, how great is that darkness! (Matthew. 6:22-23) On the levels both ofcommon discourse and scientific description, the concept of empathy has found renewed popularity. Like a bridge that spans disparate realms, the idea of empathy can reconnect neurophysiology with psychology and social theory, and reestablish the grounds for a natural concept of ethics. Specifically, it can connect mimetic theory with a possible basis in biology, since empathy seems to represent an extension ofmimetic processes across the animal kingdom. For this reason, empathy/mimesis might be the grounds for a concept of ethics based on natural observation. Drawn from a German term Einfühlung, which means "feeling into," empathy carries the concept of "getting into the feelings of someone else" (deWaal 79). As a medium for the formation of meaningful bonds and William Hurlbut15 sensitive associations, the concept of empathy has taken on, in popular discourse, the somewhat sentimental notion ofsympathy. In the scientific description, however, empathy is seen as the highest human expression of a broader biological capacity for mimesis that seems inextricable from the very progress ofthe phylogenetic process. Among the earliest life forms, organisms drew information from one another to pattern and coordinate such basic biological functions as reproduction and nurture. But with the increased complexity of multicellular creatures, new means of communication arose, making possible more flexible adaptation and sociability. Gradually the direct chemical coordination suitable for collectives or swarms gave way to richer and more individual communication between organisms of higher forms of differentiation. The externally evident demarcation ofthe head region, with its organs ofsensory perception and communication, evolved in parallel with internal cerebral structures capable ofprocessing more complex impressions of the surrounding environment and coordinating greater freedom of motion. These vital powers of action and awareness in turn came to be governed, guided and integrated by an inner felt sense of need, goal or purpose. As Leon Kass says, "desire, not DNA, is the deepest principle of life" (Kass 1994, 48). This quality of "inwardness" is paralleled by an equally complex differentiation and integration of the external "look" ofthe animal. This "look," which is the literal translation of the Latin root of our word species, is the result of a genetically determined plan as important as any internal vital organ. It provides the unity of form that reveals or selectively conceals the inner life of the organism. It communicates and coordinates vital information regarding sexual and other social interactions. This upward process ofcomplex integrated organization of the "inner life" and the external action and presentation of selfreaches its fullest expression in the human form. Along with upright posture and its freeing ofthe hands as tools of "gnostic touching," comes a reordering of the senses and a highly flexible, furless canvas of selfpresentation we call the face (Kass 1985, 287). Upwards through mammalian evolution there is a progressive refinement of the structures of the face that facilitate active and increasingly subtle communication and penetration into the life of the other. With more than 30 finely tuned muscles of facial expression and vocal control, human beings are capable of a wide array of communicative 16 Mimesis andEmpathy expressions of emotions and intentions. Paul Ekman claims to have discerned more than 1 8 forms of smiling, each with a distinct meaning (66). With upright posture came a retraction ofthe snout and bilateral stereoscopic vision. Sight replaced smell as the prominent sense. Whereas smell required direct chemical contact, and sound gave formless information, sight gave a knowing and accurate encounter with the form and unity ofwholes. Sight allowed rapid perception ofobjects and actions at distant horizons. The detached beholding of sight allowed a deeper and more accurate apprehension of... (shrink)

PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated (...) in a time‐ and spacedependent manner. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

At Theaetetus 163d-164b Socrates objects to the thesis that knowledge is perception by pointing out that a man who has seen something can still remember it, and so has knowledge of it; but this is impossible, if knowledge is perception, since he is no longer perceiving it.To this Protagoras is made to reply with two sentences at 166b 1–4: .Cornford translates ‘ For instance, do you think you will find anyone to admit that one's present memory of a past impression (...) is an impression of the same character as one had during the original experience, which is now over? It is nothing of the sort’.Cornford understands this as the suggestion that the memory and the original perception are of different things: ‘ All that the objection in fact established was that “ perception” must be stretched to include awareness of memory images’. So too Lee: ‘Protagoras’ “way out”… appears to be to say that what we now know is not properly X but rather our memory trace of X - some present πά θ ο ς quite distinct from X and very different from that ’. McDowel. (shrink)

At Theaetetus 163d-164b Socrates objects to the thesis that knowledge is perception by pointing out that a man who has seen something can still remember it, and so has knowledge of it; but this is impossible, if knowledge is perception, since he is no longer perceiving it.To this Protagoras is made to reply with two sentences at 166b 1–4:.Cornford translates ‘ For instance, do you think you will find anyone to admit that one's present memory of a past impression is (...) an impression of the same character as one had during the original experience, which is now over? It is nothing of the sort’.Cornford understands this as the suggestion that the memory and the original perception are of different things: ‘ All that the objection in fact established was that “ perception” must be stretched to include awareness of memory images’. So too Lee: ‘Protagoras’ “way out”… appears to be to say that what we now know is not properly X but rather our memory trace of X - some present πά θ ο ς quite distinct from X and very different from that ’. McDowel. (shrink)

The essays in this volume apply philosophical analysis to address three kinds of questions: What are the implications of genetic science for our understanding of nature? What might it influence in our conception of human nature? What challenges does genetic science pose for specific issues of private conduct or public policy?

Being all-good and gracious, God cannot be so envious as not to allow anything else besides him to exist. The necessitarian view thus limits God in His choice of creation and argues that God had to create in the first place out of His infinite ...

This collection of essays addresses some of the central issues in modern social and political thought, such as: the revival of Marxism and its relevance to the social sciences; the analysis of social and political structures and social movements; and the future of advanced capitalist societies.

Through discourse with international groups of physicians, we conducted a cross-cultural analysis of the types of ethical dilemmas physicians face. Qualitative analysis was used to categorise the dilemmas into seven themes, which we compared among the physicians by country of practice. These themes were a-theoretically-driven and grounded heavily within the text. We then subjected the dilemmas to an analysis of moral intensity, which represents an important theoretical perspective of ethical decision making. These constructs represent salient determinants of ethical behaviour and (...) our cross-cultural sample afforded us the opportunity to consider both the pragmatic aspects of culture, as they are perceived by physicians, as well as the theory-driven concept of moral intensity. By examining both culture and moral intensity, we hope to better elucidate the complexities of ethical decision-making determinants among physicians in their daily practice. Doing so may potentially have practical implications for ethics training of medical students and foreign physicians. (shrink)